Coming soon: FL!PMic
– an ultrafast confocal microscope for observing linear dichroism!
Check back soon: we will be launching our first complete microscopy system designed for linear dichroism microscopy! By combining two of our technologies (linear dichroism microscopy and line-scanning confocal microscopy), we are multiplying their advantages! The taste of the things to come is already in our recent paper: video-rate linear dichroism imaging, including imaging the activity of non-modified, endogenously expressed G protein Gi!
And this is an HEK293 cell expressing NB80-eGFP, a translocation-based biosensor. Upon activation of the b2-adrenergic receptor, the biosensor binds to the receptor, causing translocation of the fluorescence to the cell membrane. Binding of the biosensor to the receptor restricts the orientational freedom of the fluorescent protein, leading to emergence of linear dichroism:
Check out our publications to learn more!