Innovative Bioimaging

We are the home of Linear Dichroism (LD) microscopy

Linear dichroism microscopy visualizes differences in fluorescence images acquired with different linear polarizations of the excitation light. The principle is simple: you just acquire two images with two perpendicular polarizations of excitation light and look for differences in fluorescence intensities.

What can LD microscopy do for you? Lots! LD microscopy can detect changes in orientation of fluorescent labels with respect to membranes or filaments. And a great way to exploit this ability is by using the FL!P™ biosensors:

This is what a change in linear dichroism can look like in living cells:

This is a living HEK293 cell expressing one of our FL!P™ biosensors, responding to activation of the β2-adrenergic receptor. Find our more about FLIP biosensors and LD microscopy on our website, and in our recent publication in Science Advances:

Learn more from our pages, or contact us for more information!